What is Gut microbiome composition is it an indicator of preclinical Alzheimer’s disease?
Editor’s summary
Individuals with Alzheimer’s disease (AD) may have an altered gut microbiome, and these changes may occur early in the disease course. Now, Ferreiro et al. show that the gut microbiomes of people with preclinical AD (indicated by altered brain amyloid and tau proteins) had a different composition from that of healthy individuals. Gut microbial taxa correlated with amyloid and tau markers of preclinical AD, but not with signatures of neurodegeneration. Specific gut bacteria were identified as being associated with preclinical AD, and their inclusion improved machine learning predictions of preclinical AD status. —Orla Smith
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